Marc Shuman, MD

Honors and Awards
  • Honorary Chair Advisory Committee PUMCH Translational Medicine Center,, Peking Union Medical College Hospital, 2013
  • Phi Eta Sigma Freshman Honor Society(1 of 25 students and only one elected after one semester), Univ. of Wisconsin-Madison, 1959-1960
Publications

  1. Su Y, Liu Y, Behrens CR, Bidlingmaier S, Lee NK, Aggarwal R, Sherbenou DW, Burlingame AL, Hann BC, Simko JP, Premasekharan G, Paris PL, Shuman MA, Seo Y, Small EJ, Liu B. Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer. JCI insight 2018. PMID: 30185663


  2. Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA, Wu X, Atkinson JP, Wolf JL, Martin TG, Liu B. Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells. The Journal of clinical investigation 2016. PMID: 27841764


  3. Huang X, He Y, Dubuc AM, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens SJ, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester CM, Kim CC, Weiss WA, James CD, Shuman MA, Bader GD, Mueller S, Taylor MD, Jan YN, Jan LY. EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. Nature neuroscience 2015. PMID: 26258683


  4. Ge F, Wang DD, Li L, Lin PP, Shuman MA. WITHDRAWN: Enhanced Detection and Phenotypic and Karyotypic in Situ Characterization of Circulating Tumor Cells. The American journal of pathology 2014. PMID: 25451150


  5. Kadoch C, Li J, Wong VS, Chen L, Cha S, Munster P, Lowell CA, Shuman MA, Rubenstein JL. Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma. Clinical cancer research : an official journal of the American Association for Cancer Research 2013. PMID: 24190981


  6. Rubenstein JL, Li J, Chen L, Advani R, Drappatz J, Gerstner E, Batchelor T, Krouwer H, Hwang J, Auerback G, Kadoch C, Lowell C, Munster P, Cha S, Shuman MA, Damon LE. Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma. Blood 2012. PMID: 23197589


  7. Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY. Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes & development 2012. PMID: 22855790


  8. Wieduwilt MJ, Valles F, Issa S, Behler CM, Hwang J, McDermott M, Treseler P, O'Brien J, Shuman MA, Cha S, Damon LE, Rubenstein JL. Immunochemotherapy with intensive consolidation for primary CNS lymphoma: a pilot study and prognostic assessment by diffusion-weighted MRI. Clinical cancer research : an official journal of the American Association for Cancer Research 2012. PMID: 22228634


  9. Huang V, Place RF, Portnoy V, Wang J, Qi Z, Jia Z, Yu A, Shuman M, Yu J, Li LC. Upregulation of Cyclin B1 by miRNA and its implications in cancer. Nucleic acids research 2011. PMID: 22053081


  10. Sun C, Su KH, Valentine J, Rosa-Bauza YT, Ellman JA, Elboudwarej O, Mukherjee B, Craik CS, Shuman MA, Chen FF, Zhang X. Time-resolved single-step protease activity quantification using nanoplasmonic resonator sensors. ACS nano 2010. PMID: 20121209


  11. So AY, de la Fuente E, Walter P, Shuman M, Bernales S. The unfolded protein response during prostate cancer development. Cancer metastasis reviews 2009. PMID: 19172382


  12. Kadoch C, Dinca EB, Voicu R, Chen L, Nguyen D, Parikh S, Karrim J, Shuman MA, Lowell CA, Treseler PA, James CD, Rubenstein JL. Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model. Clinical cancer research : an official journal of the American Association for Cancer Research 2009. PMID: 19276270


  13. Rubenstein JL, Shen A, Batchelor TT, Kadoch C, Treseler P, Shuman MA. Differential gene expression in central nervous system lymphoma. Blood 2009. PMID: 19122120


  14. Roy S, Josephson SA, Fridlyand J, Karch J, Kadoch C, Karrim J, Damon L, Treseler P, Kunwar S, Shuman MA, Jones T, Becker CH, Schulman H, Rubenstein JL. Protein biomarker identification in the CSF of patients with CNS lymphoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007. PMID: 18056677


  15. Rubenstein JL, Fridlyand J, Abrey L, Shen A, Karch J, Wang E, Issa S, Damon L, Prados M, McDermott M, O'Brien J, Haqq C, Shuman M. Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007. PMID: 17312328


  16. Chan JM, Feraco A, Shuman M, Hernández-Díaz S. The epidemiology of prostate cancer--with a focus on nonsteroidal anti-inflammatory drugs. Hematology/oncology clinics of North America 2006. PMID: 16861115


  17. Rubenstein JL, Fridlyand J, Shen A, Aldape K, Ginzinger D, Batchelor T, Treseler P, Berger M, McDermott M, Prados M, Karch J, Okada C, Hyun W, Parikh S, Haqq C, Shuman M. Gene expression and angiotropism in primary CNS lymphoma. Blood 2006. PMID: 16418334


  18. Tindall D, Horne FM, Hruszkewycz A, Mohla S, Shuman M, Wang Z, Kantoff P. Symposium on androgen action in prostate cancer. Cancer research 2004. PMID: 15466216


  19. Reddy JC, Shuman MA, Aster RH. Quinine/quinidine-induced thrombocytopenia: a great imitator. Archives of internal medicine 2004. PMID: 14744847


  20. Bhatt AS, Takeuchi T, Ylstra B, Ginzinger D, Albertson D, Shuman MA, Craik CS. Quantitation of membrane type serine protease 1 (MT-SP1) in transformed and normal cells. Biological chemistry 2003. PMID: 12675519


  21. Bok RA, Hansell EJ, Nguyen TP, Greenberg NM, McKerrow JH, Shuman MA. Patterns of protease production during prostate cancer progression: proteomic evidence for cascades in a transgenic model. Prostate cancer and prostatic diseases 2003. PMID: 14663466


  22. Rubenstein JL, Combs D, Rosenberg J, Levy A, McDermott M, Damon L, Ignoffo R, Aldape K, Shen A, Lee D, Grillo-Lopez A, Shuman MA. Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compartment. Blood 2002. PMID: 12393404


  23. Rubenstein J, Fischbein N, Aldape K, Burton E, Shuman M. Hemorrhage and VEGF expression in a case of primary CNS lymphoma. Journal of neuro-oncology 2002. PMID: 12160141


  24. Elfman F, Bok R, Conn M, Shuman M, Cunha G. Urokinase plasminogen activator amino-terminal peptides inhibit development of the rat ventral prostate. Differentiation; research in biological diversity 2001. PMID: 11798065


  25. Bok RA, Halabi S, Fei DT, Rodriquez CR, Hayes DF, Vogelzang NJ, Kantoff P, Shuman MA, Small EJ. Vascular endothelial growth factor and basic fibroblast growth factor urine levels as predictors of outcome in hormone-refractory prostate cancer patients: a cancer and leukemia group B study. Cancer research 2001. PMID: 11289126


  26. Rubenstein JL, Kim J, Ozawa T, Zhang M, Westphal M, Deen DF, Shuman MA. Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia (New York, N.Y.) 2000. PMID: 11005565


  27. Takeuchi T, Shuman MA, Craik CS. Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue. Proceedings of the National Academy of Sciences of the United States of America 1999. PMID: 10500122


  29. Martin TG, Shuman MA. Interferon-induced thrombocytopenia: is it time for thrombopoietin. Hepatology (Baltimore, Md.) 1998. PMID: 9794932


  30. Shaham S, Shuman MA, Herskowitz I. Death-defying yeast identify novel apoptosis genes. Cell 1998. PMID: 9491882


  31. Evans CP, Elfman F, Cunha G, Shuman MA. Decreased prostate cancer cell migration by inhibition of the insulin-like growth factor II/Mannose-6-Phosphate receptor. Urologic oncology 1997. PMID: 21227140


  32. Evans CP, Elfman F, Parangi S, Conn M, Cunha G, Shuman MA. Inhibition of prostate cancer neovascularization and growth by urokinase-plasminogen activator receptor blockade. Cancer research 1997. PMID: 9270033


  33. Martin TG, Somberg KA, Meng YG, Cohen RL, Heid CA, de Sauvage FJ, Shuman MA. Thrombopoietin levels in patients with cirrhosis before and after orthotopic liver transplantation. Annals of internal medicine 1997. PMID: 9265428


  35. Min HY, Doyle LV, Vitt CR, Zandonella CL, Stratton-Thomas JR, Shuman MA, Rosenberg S. Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice. Cancer research 1996. PMID: 8625323


  37. Kirn DH, Fredericks D, McCutchan JA, Stites D, Shuman M. Marked elevation of the serum ferritin is highly specific for disseminated histoplasmosis in AIDS. AIDS (London, England) 1995. PMID: 8519465


  38. Kirn DH, Fredericks D, McCutchan JA, Stites D, Shuman M. Serum ferritin levels correlate with disease activity in patients with AIDS and disseminated histoplasmosis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1995. PMID: 8645808


  39. Yang Z, Cohen RL, Lui GM, Lawrence DA, Shuman MA. Thrombin increases expression of urokinase receptor by activation of the thrombin receptor. Investigative ophthalmology & visual science 1995. PMID: 7558719


  41. Bianchi E, Cohen RL, Dai A, Thor AT, Shuman MA, Smith HS. Immunohistochemical localization of the plasminogen activator inhibitor-1 in breast cancer. International journal of cancer 1995. PMID: 7532156


  43. Herndier BG, Werner A, Arnstein P, Abbey NW, Demartis F, Cohen RL, Shuman MA, Levy JA. Characterization of a human Kaposi's sarcoma cell line that induces angiogenic tumors in animals. AIDS (London, England) 1994. PMID: 7520247


  44. Bianchi E, Cohen RL, Thor AT, Todd RF, Mizukami IF, Lawrence DA, Ljung BM, Shuman MA, Smith HS. The urokinase receptor is expressed in invasive breast cancer but not in normal breast tissue. Cancer research 1994. PMID: 8313371


  46. Crowley CW, Cohen RL, Lucas BK, Liu G, Shuman MA, Levinson AD. Prevention of metastasis by inhibition of the urokinase receptor. Proceedings of the National Academy of Sciences of the United States of America 1993. PMID: 8389464


  47. Handagama P, Bainton DF, Jacques Y, Conn MT, Lazarus RA, Shuman MA. Kistrin, an integrin antagonist, blocks endocytosis of fibrinogen into guinea pig megakaryocyte and platelet alpha-granules. The Journal of clinical investigation 1993. PMID: 8423218


  48. Cohen RL, Xi XP, Crowley CW, Lucas BK, Levinson AD, Shuman MA. Effects of urokinase receptor occupancy on plasmin generation and proteolysis of basement membrane by human tumor cells. Blood 1991. PMID: 1648983


  49. Handagama PJ, Shuman MA, Bainton DF. In vivo defibrination results in markedly decreased amounts of fibrinogen in rat megakaryocytes and platelets. The American journal of pathology 1990. PMID: 2260627


  50. Bray PF, Leung CS, Shuman MA. Human platelets and megakaryocytes contain alternately spliced glycoprotein IIb mRNAs. The Journal of biological chemistry 1990. PMID: 2351656


  51. Gao SW, Morser J, McLean K, Shuman MA. Differential effect of platelets on plasminogen activation by tissue plasminogen activator, urokinase, and streptokinase. Thrombosis research 1990. PMID: 2112791


  52. Wilkinson MJ, Cohen RL, Shuman MA. A nonradioactive assay for type IV collagen degradation. Analytical biochemistry 1990. PMID: 2160204


  54. Handagama PJ, Shuman MA, Bainton DF. The origin of platelet alpha-granule proteins. Progress in clinical and biological research 1990. PMID: 1699234


  55. Roizen MF, Rodgers GM, Valone FH, Lampe GH, Benefiel DJ, Gelman S, Rapp J, Weiler JM, Ota M, Shuman MA. Anaphylactoid reactions to vascular graft material presenting with vasodilation and subsequent disseminated intravascular coagulation. Anesthesiology 1989. PMID: 2528305


  56. Handagama PJ, Shuman MA, Bainton DF. Incorporation of intravenously injected albumin, immunoglobulin G, and fibrinogen in guinea pig megakaryocyte granules. The Journal of clinical investigation 1989. PMID: 2738161


  57. Isenberg WM, McEver RP, Phillips DR, Shuman MA, Bainton DF. Immunogold-surface replica study of ADP-induced ligand binding and fibrinogen receptor clustering in human platelets. The American journal of anatomy 1989. PMID: 2773809


  58. Cohen RL, Niclas J, Lee WM, Wun TC, Crowley CW, Levinson AD, Sadler JE, Shuman MA. Effects of cellular transformation on expression of plasminogen activator inhibitors 1 and 2. Evidence for independent regulation. The Journal of biological chemistry 1989. PMID: 2498314


  59. Bray PF, Barsh G, Rosa JP, Luo XY, Magenis E, Shuman MA. Physical linkage of the genes for platelet membrane glycoproteins IIb and IIIa. Proceedings of the National Academy of Sciences of the United States of America 1988. PMID: 3186752


  60. Stricker RB, Lane PK, Leffert JD, Rodgers GM, Shuman MA, Corash L. Development of antithrombin antibodies following surgery in patients with prosthetic cardiac valves. Blood 1988. PMID: 3167212


  61. Rosa JP, Bray PF, Gayet O, Johnston GI, Cook RG, Jackson KW, Shuman MA, McEver RP. Cloning of glycoprotein IIIa cDNA from human erythroleukemia cells and localization of the gene to chromosome 17. Blood 1988. PMID: 3165296


  62. Shuman MA, Polansky JR, Merkel C, Alvarado JA. Tissue plasminogen activator in cultured human trabecular meshwork cells. Predominance of enzyme over plasminogen activator inhibitor. Investigative ophthalmology & visual science 1988. PMID: 3125123


  63. Bray PF, Rosa JP, Johnston GI, Shiu DT, Cook RG, Lau C, Kan YW, McEver RP, Shuman MA. Platelet glycoprotein IIb. Chromosomal localization and tissue expression. The Journal of clinical investigation 1987. PMID: 3479442


  64. Venook AP, Shuman MA, Corash L. Prophylactic heparin in APL. Blood 1987. PMID: 3476166


  65. Greenberg CS, Achyuthan KE, Borowitz MJ, Shuman MA. The transglutaminase in vascular cells and tissues could provide an alternate pathway for fibrin stabilization. Blood 1987. PMID: 2887223


  67. Isenberg WM, McEver RP, Phillips DR, Shuman MA, Bainton DF. The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering. The Journal of cell biology 1987. PMID: 3584243


  68. Handagama PJ, George JN, Shuman MA, McEver RP, Bainton DF. Incorporation of a circulating protein into megakaryocyte and platelet granules. Proceedings of the National Academy of Sciences of the United States of America 1987. PMID: 3468513


  69. Weisberg LJ, Shiu DT, Greenberg CS, Kan YW, Shuman MA. Localization of the gene for coagulation factor XIII a-chain to chromosome 6 and identification of sites of synthesis. The Journal of clinical investigation 1987. PMID: 3027131


  72. Rodgers GM, Shuman MA. Congenital thrombotic disorders. American journal of hematology 1986. PMID: 2937290


  73. Bray PF, Rosa JP, Lingappa VR, Kan YW, McEver RP, Shuman MA. Biogenesis of the platelet receptor for fibrinogen: evidence for separate precursors for glycoproteins IIb and IIIa. Proceedings of the National Academy of Sciences of the United States of America 1986. PMID: 3006053


  75. Shuman MA. Thrombin-cellular interactions. Annals of the New York Academy of Sciences 1986. PMID: 3032044


  77. Stenberg PE, McEver RP, Shuman MA, Jacques YV, Bainton DF. A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation. The Journal of cell biology 1985. PMID: 2411738


  78. Stricker RB, Wong D, Saks SR, Corash L, Shuman MA. Acquired Bernard-Soulier syndrome. Evidence for the role of a 210,000-molecular weight protein in the interaction of platelets with von Willebrand factor. The Journal of clinical investigation 1985. PMID: 2931453


  79. Shuman MA, Merkel CH. Urokinase binding to bovine corneal endothelial cells. Experimental eye research 1985. PMID: 4065254


  80. Greenberg CS, Miraglia CC, Rickles FR, Shuman MA. Cleavage of blood coagulation factor XIII and fibrinogen by thrombin during in vitro clotting. The Journal of clinical investigation 1985. PMID: 2860124


  81. Gitschier J, Wood WI, Tuddenham EG, Shuman MA, Goralka TM, Chen EY, Lawn RM. Detection and sequence of mutations in the factor VIII gene of haemophiliacs. Nature 1985. PMID: 2987704


  82. Rodgers GM, Shuman MA. Characterization of the interaction between factor Xa and bovine aortic endothelial cells. Biochimica et biophysica acta 1985. PMID: 3970981


  83. Greenberg CS, Shuman MA. Specific binding of blood coagulation factor XIIIa to thrombin-stimulated platelets. The Journal of biological chemistry 1984. PMID: 6150044


  85. Stricker RB, Shuman MA. Aplastic anemia complicating systemic lupus erythematosus: response to androgens in two patients. American journal of hematology 1984. PMID: 6465136


  86. Stenberg PE, Shuman MA, Levine SP, Bainton DF. Redistribution of alpha-granules and their contents in thrombin-stimulated platelets. The Journal of cell biology 1984. PMID: 6229546


  88. Rodgers GM, Shuman MA. Prothrombin is activated on vascular endothelial cells by factor Xa and calcium. Proceedings of the National Academy of Sciences of the United States of America 1983. PMID: 6580622


  90. Rodgers GM, Donaldson VH, Shuman MA. Radioisotopic measurement of plasma kallikrein. Thrombosis research 1982. PMID: 6924801


  91. Rodgers GM, Shuman MA. Acquired cyclic neutropenia: successful treatment with prednisone. American journal of hematology 1982. PMID: 7137168


  92. Greenberg CS, Shuman MA. The zymogen forms of blood coagulation factor XIII bind specifically to fibrinogen. The Journal of biological chemistry 1982. PMID: 7076665


  93. Savion N, Isaacs JD, Shuman MA, Gospodarowicz D. Proliferation and differentiation of bovine corneal endothelial cells in culture. Metabolic, pediatric, and systemic ophthalmology 1982. PMID: 6764247


  94. Isaacs J, Savion N, Gospodarowicz D, Shuman MA. Effect of cell density on thrombin binding to a specific site on bovine vascular endothelial cells. The Journal of cell biology 1981. PMID: 7287820


  95. Savion N, Isaacs JD, Gospodarowicz D, Shuman MA. Internalization and degradation of thrombin and up regulation of thrombin-binding sites in corneal endothelial cells. The Journal of biological chemistry 1981. PMID: 6260801


  96. Isaacs JD, Savion N, Gospodarowicz D, Fenton JW, Shuman MA. Covalent binding of thrombin to specific sites on corneal endothelial cells. Biochemistry 1981. PMID: 6258640


  97. Linker CA, Newcom SR, Nilsson CM, Wolf JL, Shuman MA. Combined idiopathic neutropenia and thrombocytopenia: evidence for an immune basis for the syndrome. Annals of internal medicine 1980. PMID: 7212480


  98. Shuman MA, Levine SP. Relationship between secretion of platelet Factor 4 and thrombin generation during in vitro blood clotting. The Journal of clinical investigation 1980. PMID: 6243308


  99. Fehrenbacher L, Gospodarowicz D, Shuman MA. Synthesis of plasminogen activator by bovine corneal endothelial cells. Experimental eye research 1979. PMID: 520428


  100. Shuman MA, Botney M, Fenton JW. Thrombin-induced platelet secretion. Further evidence for a specific pathway. The Journal of clinical investigation 1979. PMID: 376555


  101. Zetter BR, Johnson LK, Shuman MA, Gospodarowicz D. The isolation of vascular endothelial cell lines with altered cell surface and platelet-binding properties. Cell 1978. PMID: 688381


  102. Shuman MA, Levine SP. Thrombin generation and secretion of platelet Factor 4 during blood clotting. The Journal of clinical investigation 1978. PMID: 207723


  103. Shuman MA, Majerus PW. The measurement of thrombin in clotting blood by radioimmunoassay. The Journal of clinical investigation 1976. PMID: 993343


  104. Shuman MA, Tollefsen DM, Majerus PW. The binding of human and bovine thrombin to human platelets. Blood 1976. PMID: 812572


  105. Neu LT, Shuman MA, Brown EB. Letter: Polycythemia vera and acute leukemia. Annals of internal medicine 1975. PMID: 1060392


  106. Shuman MA, Majerus PW. The perturbation of thrombin binding to human platelets by anions. The Journal of clinical investigation 1975. PMID: 1159095


  107. Wiley JS, Ellory JC, Shuman MA, Shaller CC, Cooper RA. Characteristics of the membrane defect in the hereditary stomatocytosis syndrome. Blood 1975. PMID: 1148392